SCIENTIFIC POSTER
Functional characterization of healthy and disease-related 3D neurospheres assembled using human iPSC-derived neurons and astrocytes
Neural 3D spheroids are a rapidly developing technology with great potential for understanding brain development and neuronal diseases.
https://vids.moleculardevices.com/watch/h69HhcjkQz3J7ceBTdQMcw
They provide a more advanced and biologically relevant system for basic research and high-throughput drug discovery, including compound profiling and toxicity testing.
In this poster, we explore how this biological system of 3D neurospheres paired with a detailed analysis of calcium oscillations demonstrates a promising and informative tool for disease modeling and phenotypic functional evaluation that could be used for compound testing.
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Imaging
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FLIPR Penta High-Throughput Cellular Screening System; peak pro 2; AcuityXpress High-Content Informatic; ImageXpress Micro Confocal High-Content Imaging System
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701Rn000005ZNRwIAO
Title
Functional characterization of healthy and disease-related 3D neurospheres assembled using human iPSC-derived neurons and astrocytes
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