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What you will find in this eBook

Development of more complex, biologically relevant, and predictive cell-based assays for compound screening is a primary challenge in drug discovery. The integration of three-dimensional (3D) assay models is becoming more widespread to drive translational biology. Specifically, 3D cultures offer the advantage of closely recapitulating aspects of human tissues including the architecture, cell organization, cell-cell and cell-matrix interactions, and more physiologically-relevant diffusion characteristics.

This ebook highlights the 3D cell culture imaging and analysis advantage and includes a few 3D cell model applications as well as tips and techniques for optimizing your 3D assay workflow.

  • Applications

  • Physiologically-relevant tissue models using high-throughput organ-on-a-chip platform
  • Functional evaluation of neurotoxic and neuroactive compound effects in iPSC-derived 3D neural co-cultures
  • High-content assay for morphological characterization of neuronal development in 3D matrix
  • Assessment of drug effects on cardiomyocyte physiology using human iPSC-derived cardiac spheroids
  • Using spheroid models to develop relevant highthroughput assays with quantitative endpoints
  • Tips and Techniques

  • Automated 3D cell culture and screening by imaging and flow cytometry
  • Automation of 3D spheroid cultures in ultra-low attachment plates
  • Multi-parameter imaging assay for measuring toxicity in a tumor model
  • Measuring mitochondrial shape and distribution
  • Increase sensitivity in no-wash assays using confocal imaging

Sample pages

3D Imaging Advantage
3D Imaging Advantage
Organ-on-a-chip Platform
Organ-on-a-chip Platform
Neural Co-culture Platform
Neural Co-culture Platform
3D Hydrogel
3D Hydrogel
Automated 3D Cell Culture and Screening
Automated 3D Cell Culture and Screening

SIMPLIFY 3D CELL
CULTURE IMAGING AND
ANALYSIS

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Capture True 3D Cell Culture Insights

Whatever your imaging requirement, we have a solution
that will meet the needs of your lab and your budget.

3D Cellular Imaging Systems

Our ImageXpress portfolio of cellular imaging systems and analysis software offers innovative capabilities for evaluating complex and emerging 3D cell culture-based models such as:

  • Organoids
  • Spheroids
  • Whole organisms
  • Induced Pluripotent Stem Cell (iPSC)-derived cell models
  • Organ-on-a-chip technologies
 
Imagexpress Pico

ImageXpress Pico

Automated Cell Imaging System

ImageXpress Nano

Automated Imaging System

ImageXpress Micro 4

High-Content Imaging System

ImageXpress Micro
Confocal

High-Content Imaging System

CAMERA

5 megaPixel CMOS

4.7 megaPixel CMOS

>4 megaPixel CMOS

>4 megaPixel CMOS

FIELD OF VIEW 10X

1.93 mm2

1.85 mm2

1.96 mm2

1.96 mm2

OBJECTIVES

4x-63x Air

2x-60x Air

Air (1x-100x), Oil (40x, 60x, 100x)

Air (1x-100x),
Oil (40x, 60x, 100x),
and Water (20x, 40x, 60x)

FILTERS CHANGER

5 position filter cube changer

5 position filter cube changer

5 position filter cube changer

8 position emission wheel and
5 position dichroic filter wheel

AUTOFOCUS

LED+ image autofocus

Laser+image autofocus

Laser+image autofocus

Laser+image autofocus

PLATES

Up to 384-well plates

Up to 1536-well plates

Up to 1536-well plates

Up to 1536-well plates

TEMPERATURE CONTROL
OPTION

done

done

done

done

Find which system is right for you

Our friendly team will be happy to answer your questions and discuss your application needs in more detail with no obligation.