APPLICATION NOTE

Leveraging microalgae metabolism to produce natural food dyes: an automated screening approach

Streamlining clonal selection and maintaining integrity in bio-production through quantitative fluorescent screening and easy-to-use software

The food industry's interest in microalgae is increasing due to the growing demand for natural and sustainable food ingredients. Fermentalg® is utilizing microalgae metabolism to develop and screen multiple strains of G. sulphuraria that produce a natural blue pigment (BLUE ORIGINS®) with low pH and high temperature stability. Through automated colony screening using the QPix® 420 system, they were able to quickly identify desired clones with high concentrations of C-phycocyanin, expediting the scale-up of microalgae-based natural pigment production. This highlights the promising potential of high throughput automation for the future development of microalgal products.

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https://info.moleculardevices.com/app-note-leveraging-microalgae-metabolism-to-produce-natural-food-dyes-an-automated-screening-approac?product_family__c=QPix&product_primary_application__c=QPix%20400%20Series%20Microbial%20Colony%20Pickers;%20IN%20Carta%20Image%20Analysis%20Software&cmp=7014u0000017elMAAQ

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Learn more about the systems behind the methods:

QPix 400 Series

Fully automate synthetic biology workﬂows for DNA assembly, antibody discovery and protein engineering

The QPix® 400 Series Microbial Colony Pickers combine intelligent image analysis with precise automation for fast and efficient screening of large libraries. With a variety of data tracking and assay tools, the QPix Software streamlines the control and management of complex and iterative processes.

https://main--moleculardevices--hlxsites.hlx.page/products/clone-screening/microbial-screening/qpix-400-series-microbial-colony-pickers

Automate several sample prep and plate handling processes such as transfer of bacterial liquid culture and plating on agar
Streamline your workﬂow with scalable automation – pick up to 30,000 colonies per day
Electronic data tracking for well-documented data control
Sterile environment with customizable HEPA ﬁltration options

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Streamline your workflow when you pair the DispenCell with the CloneSelect Imager FL

The all-new CloneSelect Imager FL adds high contrast multichannel fluorescent technology in addition to the standard white light imaging that allows for accurate single-cell detection and proof of monoclonality at day 0. Identify and verify gene edits with comparative confluence assays.

Benefits

Digitally record single-cell evidence and confluency for regulatory audits and submissions.
Image cells non-invasively at multiple time points to monitor colony formation
Screen using high-resolution white light imaging
Deliver real-time results with on-the-fly analysis
Automation and integration-ready

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DispenCell with the CloneSelect Imager FL

https://main--moleculardevices--hlxsites.hlx.page/products/clone-screening/single-cell-isolation/dispencell-single-cell-dispenser

ClonePix Series

Automate antibody discovery and cell line development workﬂows

Screen more clones with the ClonePix® Series in less time with monoclonal veriﬁcation on day zero, then screen and pick for highest producers in weeks, not months.